Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2197552..2198240 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag PQK93_RS10260 Protein ID WP_003409958.1
Coordinates 2197552..2197971 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag PQK93_RS10265 Protein ID WP_003409968.1
Coordinates 2197980..2198240 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS10230 (PQK93_10230) 2192558..2192863 + 306 Protein_2021 ABC transporter permease -
PQK93_RS10235 (PQK93_10235) 2192859..2192939 + 81 Protein_2022 hypothetical protein -
PQK93_RS10240 (PQK93_10240) 2193047..2193895 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
PQK93_RS10245 (PQK93_10245) 2193858..2195303 - 1446 WP_003409946.1 APC family permease -
PQK93_RS10250 (PQK93_10250) 2195482..2196168 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
PQK93_RS10255 (PQK93_10255) 2196359..2197327 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
PQK93_RS10260 (PQK93_10260) 2197552..2197971 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS10265 (PQK93_10265) 2197980..2198240 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQK93_RS10270 (PQK93_10270) 2198383..2200059 + 1677 WP_105537234.1 PecA family PE domain-processing aspartic protease -
PQK93_RS10275 (PQK93_10275) 2200047..2200700 - 654 WP_003409976.1 cutinase Cfp21 -
PQK93_RS10280 (PQK93_10280) 2200815..2201045 + 231 WP_003409980.1 DUF167 domain-containing protein -
PQK93_RS10285 (PQK93_10285) 2201130..2202041 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
PQK93_RS10290 (PQK93_10290) 2202150..2202749 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T270349 WP_003409958.1 NZ_CP117298:c2197971-2197552 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT270349 WP_003409968.1 NZ_CP117298:c2198240-2197980 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References