270344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1925304..1925917 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag PQK93_RS08980 Protein ID WP_003408465.1
Coordinates 1925304..1925693 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag PQK93_RS08985 Protein ID WP_003408469.1
Coordinates 1925690..1925917 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS08945 (PQK93_08945) 1920934..1921848 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
PQK93_RS08950 (PQK93_08950) 1921851..1922681 + 831 WP_003408448.1 cyclase family protein -
PQK93_RS08955 (PQK93_08955) 1922681..1923031 + 351 WP_003898986.1 cupin domain-containing protein -
PQK93_RS08960 (PQK93_08960) 1923084..1923901 + 818 Protein_1768 3-keto-5-aminohexanoate cleavage protein -
PQK93_RS08965 (PQK93_08965) 1923915..1924694 + 780 WP_003408460.1 IclR family transcriptional regulator -
PQK93_RS08975 (PQK93_08975) 1925125..1925256 + 132 Protein_1770 IS3 family transposase -
PQK93_RS08980 (PQK93_08980) 1925304..1925693 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS08985 (PQK93_08985) 1925690..1925917 - 228 WP_003408469.1 antitoxin Antitoxin
PQK93_RS08990 (PQK93_08990) 1926135..1927619 + 1485 WP_010950580.1 biotin carboxylase -
PQK93_RS08995 (PQK93_08995) 1927616..1928863 + 1248 WP_003408476.1 serine hydrolase -
PQK93_RS09000 (PQK93_09000) 1928906..1929325 - 420 WP_003408483.1 hypothetical protein -
PQK93_RS09005 (PQK93_09005) 1929315..1930025 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T270344 WP_003408465.1 NZ_CP117298:c1925693-1925304 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT270344 WP_003408469.1 NZ_CP117298:c1925917-1925690 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References