Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1753237..1753850 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag PQK93_RS08230 Protein ID WP_003407786.1
Coordinates 1753446..1753850 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag PQK93_RS08225 Protein ID WP_009935474.1
Coordinates 1753237..1753440 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS08210 (PQK93_08210) 1748501..1751404 + 2904 WP_105537182.1 MMPL family transporter -
PQK93_RS08215 (PQK93_08215) 1751414..1751860 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
PQK93_RS08220 (PQK93_08220) 1751895..1753184 + 1290 WP_003407781.1 threonine ammonia-lyase -
PQK93_RS08225 (PQK93_08225) 1753237..1753440 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQK93_RS08230 (PQK93_08230) 1753446..1753850 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
PQK93_RS08235 (PQK93_08235) 1753867..1755609 - 1743 Protein_1624 malto-oligosyltrehalose trehalohydrolase -
PQK93_RS08240 (PQK93_08240) 1755602..1757093 - 1492 Protein_1625 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T270343 WP_003407786.1 NZ_CP117298:1753446-1753850 [Mycobacterium tuberculosis variant bovis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT270343 WP_009935474.1 NZ_CP117298:1753237-1753440 [Mycobacterium tuberculosis variant bovis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References