Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1575210..1575865 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag PQK93_RS07455 Protein ID WP_003407268.1
Coordinates 1575210..1575611 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag PQK93_RS07460 Protein ID WP_003407272.1
Coordinates 1575608..1575865 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS07440 (PQK93_07440) 1571055..1572440 - 1386 WP_003407260.1 cytochrome P450 -
PQK93_RS07445 (PQK93_07445) 1572518..1573552 + 1035 WP_003407264.1 AraC family transcriptional regulator -
PQK93_RS07450 (PQK93_07450) 1573598..1574955 - 1358 Protein_1467 PE family protein -
PQK93_RS07455 (PQK93_07455) 1575210..1575611 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS07460 (PQK93_07460) 1575608..1575865 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
PQK93_RS07465 (PQK93_07465) 1575948..1576907 - 960 WP_003407276.1 alpha/beta hydrolase -
PQK93_RS07470 (PQK93_07470) 1576932..1577894 - 963 WP_003407279.1 alpha/beta hydrolase -
PQK93_RS07475 (PQK93_07475) 1577893..1578630 + 738 WP_031647000.1 lysoplasmalogenase -
PQK93_RS07480 (PQK93_07480) 1578711..1580678 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T270341 WP_003407268.1 NZ_CP117298:c1575611-1575210 [Mycobacterium tuberculosis variant bovis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT270341 WP_003407272.1 NZ_CP117298:c1575865-1575608 [Mycobacterium tuberculosis variant bovis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References