Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1541217..1542267 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag PQK93_RS07305 Protein ID WP_003407164.1
Coordinates 1541217..1542038 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag PQK93_RS07310 Protein ID WP_003407167.1
Coordinates 1542031..1542267 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS07285 (PQK93_07285) 1536775..1537437 - 663 WP_010950531.1 hypothetical protein -
PQK93_RS07290 (PQK93_07290) 1537434..1538219 - 786 WP_010950532.1 hypothetical protein -
PQK93_RS07295 (PQK93_07295) 1538510..1540471 - 1962 WP_010950533.1 sigma-F factor regulator -
PQK93_RS07300 (PQK93_07300) 1540610..1540996 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
PQK93_RS07305 (PQK93_07305) 1541217..1542038 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
PQK93_RS07310 (PQK93_07310) 1542031..1542267 + 237 WP_003407167.1 hypothetical protein Antitoxin
PQK93_RS07315 (PQK93_07315) 1542339..1543544 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
PQK93_RS07320 (PQK93_07320) 1543847..1544632 + 786 WP_003407180.1 lipoprotein LprF -
PQK93_RS07325 (PQK93_07325) 1544828..1546298 + 1471 Protein_1442 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T270340 WP_003407164.1 NZ_CP117298:1541217-1542038 [Mycobacterium tuberculosis variant bovis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT270340 WP_003407167.1 NZ_CP117298:1542031-1542267 [Mycobacterium tuberculosis variant bovis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References