Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 4633185..4633735 Replicon chromosome
Accession NC_017571
Organism Shewanella baltica BA175

Toxin (Protein)


Gene name parE Uniprot ID G0ASV5
Locus tag SBAL175_RS19905 Protein ID WP_006079800.1
Coordinates 4633436..4633735 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID G0ASV4
Locus tag SBAL175_RS19900 Protein ID WP_006079801.1
Coordinates 4633185..4633427 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBAL175_RS19875 4628213..4629433 + 1221 WP_006079806.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -
SBAL175_RS19880 4629438..4629971 + 534 WP_006079805.1 hotdog family protein -
SBAL175_RS19885 4630137..4630862 + 726 WP_006079804.1 3-ketoacyl-ACP reductase FabG2 -
SBAL175_RS19890 4630863..4632122 + 1260 WP_006079803.1 beta-ketoacyl-ACP synthase -
SBAL175_RS19895 4632151..4632894 + 744 WP_006079802.1 hypothetical protein -
SBAL175_RS19900 4633185..4633427 + 243 WP_006079801.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SBAL175_RS19905 4633436..4633735 + 300 WP_006079800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SBAL175_RS19910 4634143..4634844 - 702 WP_006079799.1 hypothetical protein -
SBAL175_RS19915 4634920..4635624 - 705 WP_006079798.1 hypothetical protein -
SBAL175_RS19920 4636201..4636677 + 477 WP_006079797.1 GNAT family N-acetyltransferase -
SBAL175_RS19925 4636730..4637917 - 1188 WP_006079796.1 benzoate/H(+) symporter BenE family transporter -
SBAL175_RS19930 4638081..4638656 + 576 WP_006079795.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-58)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11577.37 Da        Isoelectric Point: 9.5972

>T27034 WP_006079800.1 NC_017571:4633436-4633735 [Shewanella baltica BA175]
MKNKRYKLSKLAQTHLLKIKDYTIQHFSESQWHKYKESLISGFQMLADNPGLGRSCDDIYPNGFYFPIGKHTAYFTKEDD
FILIVAMLGQPQLPQNHLK

Download         Length: 300 bp

>T27034 NC_017571:4633436-4633735 [Shewanella baltica BA175]
ATGAAAAATAAACGCTATAAACTGAGTAAGTTAGCTCAGACTCATTTACTAAAGATTAAAGACTACACCATTCAACACTT
TTCTGAGTCGCAGTGGCACAAATACAAAGAAAGCCTAATATCTGGCTTTCAAATGTTAGCCGATAACCCCGGATTAGGCA
GAAGCTGCGATGATATTTACCCCAACGGTTTCTACTTTCCTATTGGTAAACACACCGCCTACTTCACAAAAGAAGACGAC
TTCATCCTCATCGTTGCCATGTTAGGCCAACCACAACTACCCCAAAACCACCTGAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.17 Da        Isoelectric Point: 5.0621

>AT27034 WP_006079801.1 NC_017571:4633185-4633427 [Shewanella baltica BA175]
VQTLTANDAKRNFGELLLNAQREPIKISKNNKDAVVVMSIHDFEQLEAMKADYLKHCFNAAKEDLAKANVVDGEDFLNAL

Download         Length: 243 bp

>AT27034 NC_017571:4633185-4633427 [Shewanella baltica BA175]
GTGCAAACATTAACCGCCAATGACGCCAAACGAAATTTCGGTGAGTTACTGCTAAATGCTCAACGCGAACCCATCAAGAT
CAGTAAAAACAATAAAGATGCGGTTGTCGTGATGTCTATCCACGACTTCGAACAGCTTGAGGCGATGAAAGCGGATTACC
TTAAACACTGCTTCAACGCTGCTAAAGAAGACTTAGCGAAAGCTAATGTCGTTGATGGCGAAGATTTTCTTAACGCCCTG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0ASV5

Antitoxin

Source ID Structure
AlphaFold DB A0A366IUA2

References