Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1385932..1386620 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag PQK93_RS06630 Protein ID WP_003406304.1
Coordinates 1386189..1386620 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag PQK93_RS06625 Protein ID WP_003406302.1
Coordinates 1385932..1386192 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS06605 (PQK93_06605) 1381510..1382334 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
PQK93_RS06610 (PQK93_06610) 1382339..1383520 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
PQK93_RS06615 (PQK93_06615) 1383597..1384697 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
PQK93_RS06620 (PQK93_06620) 1384867..1385856 + 990 WP_003406301.1 malate dehydrogenase -
PQK93_RS06625 (PQK93_06625) 1385932..1386192 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
PQK93_RS06630 (PQK93_06630) 1386189..1386620 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS06635 (PQK93_06635) 1386643..1388331 - 1689 WP_003910308.1 PE family protein -
PQK93_RS06640 (PQK93_06640) 1388511..1389371 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
PQK93_RS06645 (PQK93_06645) 1389452..1390282 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
PQK93_RS06650 (PQK93_06650) 1390339..1390632 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
PQK93_RS06655 (PQK93_06655) 1390629..1390898 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T270338 WP_003406304.1 NZ_CP117298:1386189-1386620 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT270338 WP_003406302.1 NZ_CP117298:1385932-1386192 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References