Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 842810..843519 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQK93_RS03985 Protein ID WP_105537201.1
Coordinates 843091..843519 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag PQK93_RS03980 Protein ID WP_003403834.1
Coordinates 842810..843067 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS03975 (PQK93_03975) 839990..842719 + 2730 WP_274479920.1 PE family protein -
PQK93_RS03980 (PQK93_03980) 842810..843067 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
PQK93_RS03985 (PQK93_03985) 843091..843519 + 429 WP_105537201.1 type II toxin-antitoxin system VapC family toxin Toxin
PQK93_RS03990 (PQK93_03990) 843600..843737 - 138 WP_003403839.1 hypothetical protein -
PQK93_RS03995 (PQK93_03995) 843896..844141 + 246 WP_003403841.1 hypothetical protein -
PQK93_RS04000 (PQK93_04000) 844210..845094 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
PQK93_RS04005 (PQK93_04005) 845105..846277 - 1173 WP_010950438.1 acyl-CoA dehydrogenase family protein -
PQK93_RS04010 (PQK93_04010) 846284..847816 - 1533 WP_010950439.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15815.23 Da        Isoelectric Point: 7.5536

>T270332 WP_105537201.1 NZ_CP117298:843091-843519 [Mycobacterium tuberculosis variant bovis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRPLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT270332 WP_003403834.1 NZ_CP117298:842810-843067 [Mycobacterium tuberculosis variant bovis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References