Detailed information of TA system TA027033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4582769..4584357
• Replicon: chromosome
• Accession: NC_017571
• Organism: Shewanella baltica BA175

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: G0AS32
• Locus tag: SBAL175_RS19670
• Protein ID: WP_006079859.1
• Coordinates: 4582769..4584076 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SBAL175_RS19675
• Protein ID: WP_006079858.1
• Coordinates: 4584076..4584357 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL175_RS19645	4578212..4578862	+	651	WP_006079864.1	GTP cyclohydrolase I FolE	-
SBAL175_RS19650	4579089..4579730	-	642	WP_006079863.1	orotate phosphoribosyltransferase	-
SBAL175_RS19655	4579907..4580620	-	714	WP_006079862.1	ribonuclease PH	-
SBAL175_RS19660	4581159..4582022	+	864	WP_006079861.1	YicC family protein	-
SBAL175_RS19665	4582169..4582495	+	327	WP_006079860.1	hypothetical protein	-
SBAL175_RS19670	4582769..4584076	-	1308	WP_006079859.1	type II toxin-antitoxin system HipA family toxin	Toxin
SBAL175_RS19675	4584076..4584357	-	282	WP_006079858.1	helix-turn-helix domain-containing protein	Antitoxin
SBAL175_RS19680	4584747..4585880	-	1134	WP_006079857.1	hypothetical protein	-
SBAL175_RS19685	4586062..4586700	+	639	WP_006079856.1	multidrug MFS transporter	-
SBAL175_RS19690	4586735..4587472	-	738	WP_006079855.1	pyrimidine 5'-nucleotidase	-
SBAL175_RS19695	4587712..4588611	+	900	WP_006079854.1	LysR family transcriptional regulator	-
SBAL175_RS19700	4588774..4589190	+	417	WP_006079853.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 48669.12 Da
• Isoelectric Point: 7.2835

>T27033 WP_006079859.1 NC_017571:c4584076-4582769 [Shewanella baltica BA175]
MAVLDVYMNGYLVGELTKSSTGSHQFAYAQQWLAIPGSRPISLSMPLRNQAYKGDEVYNFFDNLLPDNHDVRNRVVARHN
ADSTQAFDLLAKIGQDSVGALQLVPHGQPPFDIKKIESKPLSDKQLEKVLKGYQSNIPLGMLADDDDFRISIAGAQEKTA
LLKLNGEWRLPIKSTPTTHIIKLPIGEINSHSHSIDMSDSVENEYLCMMIVREFGLDAPQCSIIKVGDIKALAVERFDRR
LSSDGTWIMRLPQEDFCQTLNIPPAKKYESHGGPGIEQIMPYLLGSMNSERDRYNFIKSQVLFWLLAATDGHAKNFSLFI
EADGGYRLTPFYDILSMYPVIGGKGLNIRDAKLAMGLKAAKGKKYQINQIFPRHFILTAKAVGFDTGIMMEMMRDIADKV
EAVVVKVKAQLPDDFPPHIQDSILNGLTDRIKRIA

Nucleotide

• Length: 1308 bp

>T27033 NC_017571:c4584076-4582769 [Shewanella baltica BA175]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGGGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAGTGGCTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAATCAAGCCTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGACAATCACGACGTGAGAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACACAAGCATTTGACCTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTGTCCCCCATGG
TCAGCCTCCCTTTGATATAAAAAAGATTGAGTCTAAACCGCTATCCGATAAGCAGTTGGAAAAAGTACTTAAGGGTTATC
AGTCCAATATCCCCTTAGGCATGCTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTTAAACTCAATGGAGAGTGGCGATTACCTATCAAATCGACACCCACTACCCATATCATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAGATATGTCTGACAGTGTCGAGAATGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGCTTAGATGCACCCCAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCTTCAGATGGCACATGGATTATGCGGCTGCCCCAAGAAGACTTTTGTCAGACATTAAATATCCCACCAGCGAAGAA
ATATGAGAGCCATGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCGGAGCGCGACAGAT
ATAACTTCATCAAGTCTCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGTCATGCTAAAAACTTCTCACTCTTCATC
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCCGTCATTGGTGGTAAAGGTCTAAA
TATTCGTGATGCCAAGCTCGCTATGGGCCTCAAAGCGGCTAAGGGTAAGAAGTATCAAATCAATCAAATTTTTCCACGGC
ACTTTATCCTAACAGCCAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCGCGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTTAAGGTTAAAGCGCAGCTGCCAGATGATTTTCCACCACACATACAGGATTCAATATTGAACGGTTT
AACTGACAGAATTAAGCGCATAGCTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10697.12 Da
• Isoelectric Point: 7.0147

>AT27033 WP_006079858.1 NC_017571:c4584357-4584076 [Shewanella baltica BA175]
MKVTNAKQLSTYLKDARLNAQLSQSKVASKVGIRQDTVSSFELNPDSTKLETLFKILSALNLELDIKVRNPQLVDERRHD
NATVPEQEWKEEW

Nucleotide

• Length: 282 bp

>AT27033 NC_017571:c4584357-4584076 [Shewanella baltica BA175]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCTAGCTTTGAGTTGAACCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCCACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: G0AS32