Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 711705..712330 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag PQK93_RS03260 Protein ID WP_003403218.1
Coordinates 711929..712330 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag PQK93_RS03255 Protein ID WP_003403213.1
Coordinates 711705..711932 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS03230 (PQK93_03230) 706884..707105 - 222 WP_003898525.1 DUF4926 domain-containing protein -
PQK93_RS03235 (PQK93_03235) 707247..707852 + 606 WP_003898526.1 hypothetical protein -
PQK93_RS03240 (PQK93_03240) 707871..710438 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
PQK93_RS03245 (PQK93_03245) 710522..711271 + 750 WP_003898528.1 hypothetical protein -
PQK93_RS03250 (PQK93_03250) 711268..711510 + 243 WP_003403210.1 hypothetical protein -
PQK93_RS03255 (PQK93_03255) 711705..711932 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
PQK93_RS03260 (PQK93_03260) 711929..712330 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
PQK93_RS03265 (PQK93_03265) 712459..712542 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
PQK93_RS03270 (PQK93_03270) 712561..713643 + 1083 WP_031702118.1 galactose-1-phosphate uridylyltransferase -
PQK93_RS03275 (PQK93_03275) 713640..714731 + 1092 WP_003403225.1 galactokinase -
PQK93_RS03280 (PQK93_03280) 715126..716283 + 1158 WP_003903091.1 hypothetical protein -
PQK93_RS03285 (PQK93_03285) 716294..717241 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T270325 WP_003403218.1 NZ_CP117298:711929-712330 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT270325 WP_003403213.1 NZ_CP117298:711705-711932 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References