Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 364715..365358 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag PQK93_RS01600 Protein ID WP_003401566.1
Coordinates 364933..365358 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag PQK93_RS01595 Protein ID WP_003401563.1
Coordinates 364715..364936 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS01570 (PQK93_01570) 359792..360595 - 804 WP_003401540.1 Stf0 family sulphotransferase -
PQK93_RS01575 (PQK93_01575) 360605..362002 - 1398 WP_003401544.1 sulfatase -
PQK93_RS01580 (PQK93_01580) 362181..363998 + 1818 WP_235733064.1 PE family protein -
PQK93_RS01585 (PQK93_01585) 364141..364368 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
PQK93_RS01590 (PQK93_01590) 364365..364667 + 303 WP_003401560.1 toxin-antitoxin system toxin -
PQK93_RS01595 (PQK93_01595) 364715..364936 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
PQK93_RS01600 (PQK93_01600) 364933..365358 + 426 WP_003401566.1 PIN domain nuclease Toxin
PQK93_RS01605 (PQK93_01605) 365494..366126 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
PQK93_RS01610 (PQK93_01610) 366123..367031 + 909 WP_003900117.1 protochlorophyllide reductase -
PQK93_RS01615 (PQK93_01615) 367039..367629 - 591 WP_234712434.1 hypothetical protein -
PQK93_RS01620 (PQK93_01620) 367622..367672 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T270319 WP_003401566.1 NZ_CP117298:364933-365358 [Mycobacterium tuberculosis variant bovis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT270319 WP_003401563.1 NZ_CP117298:364715-364936 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References