Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71283..71916 Replicon chromosome
Accession NZ_CP117298
Organism Mycobacterium tuberculosis variant bovis strain OLF-AH-2022-TB-0122

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag PQK93_RS00365 Protein ID WP_003400580.1
Coordinates 71515..71916 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BR76
Locus tag PQK93_RS00360 Protein ID WP_011799070.1
Coordinates 71283..71522 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQK93_RS00345 (PQK93_00345) 66580..68019 + 1440 WP_003901784.1 FAD-binding oxidoreductase -
PQK93_RS00350 (PQK93_00350) 68075..68236 + 162 WP_003899796.1 hypothetical protein -
PQK93_RS00355 (PQK93_00355) 68277..71216 + 2940 WP_003901785.1 UPF0182 family protein -
PQK93_RS00360 (PQK93_00360) 71283..71522 + 240 WP_011799070.1 hypothetical protein Antitoxin
PQK93_RS00365 (PQK93_00365) 71515..71916 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
PQK93_RS00370 (PQK93_00370) 71968..74205 - 2238 WP_003400583.1 NADP-dependent isocitrate dehydrogenase -
PQK93_RS00375 (PQK93_00375) 74323..74892 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator -
PQK93_RS00380 (PQK93_00380) 74995..75906 + 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T270316 WP_003400580.1 NZ_CP117298:71515-71916 [Mycobacterium tuberculosis variant bovis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8745.89 Da        Isoelectric Point: 8.5960

>AT270316 WP_011799070.1 NZ_CP117298:71283-71522 [Mycobacterium tuberculosis variant bovis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEVIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BR76

References