Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4248825..4249606 Replicon chromosome
Accession NZ_CP117294
Organism Salmonella enterica subsp. enterica serovar Typhi strain S1

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PRW94_RS21015 Protein ID WP_000626103.1
Coordinates 4248825..4249316 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PRW94_RS21020 Protein ID WP_001110456.1
Coordinates 4249313..4249606 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW94_RS20990 (PRW94_20990) 4244592..4245956 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PRW94_RS20995 (PRW94_20995) 4245953..4246987 - 1035 WP_001195363.1 ParA family protein -
PRW94_RS21000 (PRW94_21000) 4247201..4247275 - 75 Protein_4118 helix-turn-helix domain-containing protein -
PRW94_RS21005 (PRW94_21005) 4247655..4247732 + 78 Protein_4119 porin family protein -
PRW94_RS21010 (PRW94_21010) 4247832..4248584 + 753 WP_001785756.1 non-specific acid phosphatase -
PRW94_RS21015 (PRW94_21015) 4248825..4249316 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PRW94_RS21020 (PRW94_21020) 4249313..4249606 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PRW94_RS21025 (PRW94_21025) 4249923..4250145 + 223 Protein_4123 hypothetical protein -
PRW94_RS21030 (PRW94_21030) 4250411..4251286 + 876 WP_000921674.1 AraC family transcriptional regulator -
PRW94_RS21035 (PRW94_21035) 4251283..4251570 + 288 WP_001269916.1 transcriptional regulator RtsB -
PRW94_RS21040 (PRW94_21040) 4251593..4251809 + 217 Protein_4126 hypothetical protein -
PRW94_RS21045 (PRW94_21045) 4251817..4252161 + 345 WP_100680417.1 Ig-like domain-containing protein -
PRW94_RS21050 (PRW94_21050) 4252448..4253353 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T270312 WP_000626103.1 NZ_CP117294:c4249316-4248825 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT270312 WP_001110456.1 NZ_CP117294:c4249606-4249313 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References