Detailed information of TA system TA027031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 885913..887454
• Replicon: chromosome
• Accession: NC_017571
• Organism: Shewanella baltica BA175

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: G0AXA4
• Locus tag: SBAL175_RS03730
• Protein ID: WP_006083105.1
• Coordinates: 886153..887454 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SBAL175_RS03725
• Protein ID: WP_006083106.1
• Coordinates: 885913..886149 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL175_RS03705	880941..881930	+	990	WP_006083122.1	LysR family transcriptional regulator	-
SBAL175_RS03710	881932..883299	-	1368	WP_006083121.1	MATE family efflux transporter	-
SBAL175_RS03715	883523..883813	+	291	WP_006083120.1	co-chaperone GroES	-
SBAL175_RS03720	883871..885508	+	1638	WP_006083119.1	chaperonin GroEL	-
SBAL175_RS03725	885913..886149	+	237	WP_006083106.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
SBAL175_RS03730	886153..887454	+	1302	WP_006083105.1	HipA domain-containing protein	Toxin
SBAL175_RS03735	888079..889050	-	972	WP_006083104.1	hypothetical protein	-
SBAL175_RS03740	889593..889742	+	150	WP_006083103.1	hypothetical protein	-
SBAL175_RS03745	889822..890073	-	252	WP_006083102.1	DUF2999 domain-containing protein	-
SBAL175_RS03750	890408..891904	+	1497	WP_006083101.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	htpB	731115..894195	163080

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48775.98 Da
• Isoelectric Point: 5.0861

>T27031 WP_006083105.1 NC_017571:886153-887454 [Shewanella baltica BA175]
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWVLFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLDLPRNLLISNLTTIARRIPQAIAEVVSMLPALD
ESETSFVAHYKAQLLARCERYLSFADEVRDVEV

Nucleotide

• Length: 1302 bp

>T27031 NC_017571:886153-887454 [Shewanella baltica BA175]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGCAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGTAAAATGTCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGTGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAAGATTTTGAACAACAGCTTGCTATGGCAATCGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGATTTACCACGGAATTTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGCTGAGGTAGTTTCAATGCTCCCGGCCCTCGAT
GAGAGTGAAACATCATTTGTGGCTCATTACAAAGCGCAGTTACTGGCGAGATGTGAGCGTTACCTTAGTTTTGCTGACGA
GGTCAGGGATGTGGAAGTGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8602.97 Da
• Isoelectric Point: 7.9728

>AT27031 WP_006083106.1 NC_017571:885913-886149 [Shewanella baltica BA175]
MASRLNQQSLGLLIKERRKSAVLTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIEIVSAQTSDTETNGWY

Nucleotide

• Length: 237 bp

>AT27031 NC_017571:885913-886149 [Shewanella baltica BA175]
ATGGCATCACGGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGTTCTTACTCAAGACGT
GGCAGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Structures

Toxin

• AlphaFold DB: G0AXA4