Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1390533..1391153 Replicon chromosome
Accession NZ_CP117294
Organism Salmonella enterica subsp. enterica serovar Typhi strain S1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PRW94_RS06740 Protein ID WP_001280991.1
Coordinates 1390533..1390751 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PRW94_RS06745 Protein ID WP_000344807.1
Coordinates 1390779..1391153 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW94_RS06700 (PRW94_06700) 1385756..1386325 + 570 WP_000779802.1 YbaY family lipoprotein -
PRW94_RS06705 (PRW94_06705) 1386358..1386747 - 390 WP_000961285.1 MGMT family protein -
PRW94_RS06715 (PRW94_06715) 1386978..1388528 - 1551 WP_000213129.1 EAL domain-containing protein -
PRW94_RS06720 (PRW94_06720) 1388753..1389013 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PRW94_RS06725 (PRW94_06725) 1389019..1389159 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PRW94_RS06730 (PRW94_06730) 1389215..1389685 - 471 WP_000136183.1 YlaC family protein -
PRW94_RS06735 (PRW94_06735) 1389803..1390354 - 552 WP_001278793.1 maltose O-acetyltransferase -
PRW94_RS06740 (PRW94_06740) 1390533..1390751 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PRW94_RS06745 (PRW94_06745) 1390779..1391153 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PRW94_RS06750 (PRW94_06750) 1391649..1394798 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PRW94_RS06755 (PRW94_06755) 1394821..1396014 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270304 WP_001280991.1 NZ_CP117294:c1390751-1390533 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270304 WP_000344807.1 NZ_CP117294:c1391153-1390779 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References