Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 822370..822995 Replicon chromosome
Accession NZ_CP117294
Organism Salmonella enterica subsp. enterica serovar Typhi strain S1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PRW94_RS04000 Protein ID WP_000911334.1
Coordinates 822597..822995 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PRW94_RS03995 Protein ID WP_000557549.1
Coordinates 822370..822597 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW94_RS03965 (PRW94_03965) 817541..818260 + 720 WP_000082599.1 Rha family transcriptional regulator -
PRW94_RS03970 (PRW94_03970) 818264..818467 + 204 WP_000184036.1 hypothetical protein -
PRW94_RS03975 (PRW94_03975) 818550..819005 + 456 WP_223229661.1 hypothetical protein -
PRW94_RS03980 (PRW94_03980) 819107..820228 + 1122 WP_000028980.1 hypothetical protein -
PRW94_RS03985 (PRW94_03985) 820861..821667 - 807 WP_077905073.1 DUF1460 domain-containing protein -
PRW94_RS03990 (PRW94_03990) 821942..822193 - 252 WP_001540858.1 hypothetical protein -
PRW94_RS03995 (PRW94_03995) 822370..822597 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PRW94_RS04000 (PRW94_04000) 822597..822995 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PRW94_RS04005 (PRW94_04005) 823802..824338 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PRW94_RS04010 (PRW94_04010) 824385..825017 + 633 WP_000835268.1 YfdX family protein -
PRW94_RS04015 (PRW94_04015) 825736..826317 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 815299..831440 16141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T270302 WP_000911334.1 NZ_CP117294:822597-822995 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270302 WP_000557549.1 NZ_CP117294:822370-822597 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References