Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4247286..4248067 | Replicon | chromosome |
| Accession | NZ_CP117293 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain S2 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1M4 |
| Locus tag | PRW95_RS21010 | Protein ID | WP_000626103.1 |
| Coordinates | 4247286..4247777 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1M5 |
| Locus tag | PRW95_RS21015 | Protein ID | WP_001110456.1 |
| Coordinates | 4247774..4248067 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PRW95_RS20985 (PRW95_20985) | 4243053..4244417 | - | 1365 | WP_000018529.1 | SPI-7-type island replicative DNA helicase | - |
| PRW95_RS20990 (PRW95_20990) | 4244414..4245448 | - | 1035 | WP_001195363.1 | ParA family protein | - |
| PRW95_RS20995 (PRW95_20995) | 4245662..4245736 | - | 75 | Protein_4117 | helix-turn-helix domain-containing protein | - |
| PRW95_RS21000 (PRW95_21000) | 4246116..4246193 | + | 78 | Protein_4118 | porin family protein | - |
| PRW95_RS21005 (PRW95_21005) | 4246293..4247045 | + | 753 | WP_001785756.1 | non-specific acid phosphatase | - |
| PRW95_RS21010 (PRW95_21010) | 4247286..4247777 | - | 492 | WP_000626103.1 | GNAT family N-acetyltransferase | Toxin |
| PRW95_RS21015 (PRW95_21015) | 4247774..4248067 | - | 294 | WP_001110456.1 | DUF1778 domain-containing protein | Antitoxin |
| PRW95_RS21020 (PRW95_21020) | 4248384..4248606 | + | 223 | Protein_4122 | hypothetical protein | - |
| PRW95_RS21025 (PRW95_21025) | 4248872..4249747 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| PRW95_RS21030 (PRW95_21030) | 4249744..4250031 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| PRW95_RS21035 (PRW95_21035) | 4250054..4250270 | + | 217 | Protein_4125 | hypothetical protein | - |
| PRW95_RS21040 (PRW95_21040) | 4250278..4250622 | + | 345 | WP_100680417.1 | Ig-like domain-containing protein | - |
| PRW95_RS21045 (PRW95_21045) | 4250909..4251814 | - | 906 | WP_001268195.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17675.47 Da Isoelectric Point: 7.2652
>T270297 WP_000626103.1 NZ_CP117293:c4247777-4247286 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 11005.67 Da Isoelectric Point: 8.6141
>AT270297 WP_001110456.1 NZ_CP117293:c4248067-4247774 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A718CB38 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716NSU2 |