Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4007764..4008280 Replicon chromosome
Accession NZ_CP117293
Organism Salmonella enterica subsp. enterica serovar Typhi strain S2

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PRW95_RS19685 Protein ID WP_000220578.1
Coordinates 4007764..4008048 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PRW95_RS19690 Protein ID WP_000212724.1
Coordinates 4008038..4008280 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW95_RS19670 (PRW95_19670) 4002976..4004628 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
PRW95_RS19675 (PRW95_19675) 4005037..4007175 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
PRW95_RS19680 (PRW95_19680) 4007296..4007760 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PRW95_RS19685 (PRW95_19685) 4007764..4008048 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRW95_RS19690 (PRW95_19690) 4008038..4008280 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PRW95_RS19695 (PRW95_19695) 4008358..4010271 - 1914 WP_001212152.1 BglG family transcription antiterminator -
PRW95_RS19700 (PRW95_19700) 4010288..4011028 - 741 WP_000779260.1 KDGP aldolase family protein -
PRW95_RS19705 (PRW95_19705) 4011025..4012143 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PRW95_RS19710 (PRW95_19710) 4012127..4013260 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T270295 WP_000220578.1 NZ_CP117293:c4008048-4007764 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270295 WP_000212724.1 NZ_CP117293:c4008280-4008038 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References