Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4435344..4436125 Replicon chromosome
Accession NZ_CP117292
Organism Salmonella enterica subsp. enterica serovar Typhi strain S4

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PRW96_RS21900 Protein ID WP_000626103.1
Coordinates 4435344..4435835 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PRW96_RS21905 Protein ID WP_001110456.1
Coordinates 4435832..4436125 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW96_RS21875 (PRW96_21875) 4431111..4432475 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PRW96_RS21880 (PRW96_21880) 4432472..4433506 - 1035 WP_001195363.1 ParA family protein -
PRW96_RS21885 (PRW96_21885) 4433720..4433794 - 75 Protein_4282 helix-turn-helix domain-containing protein -
PRW96_RS21890 (PRW96_21890) 4434174..4434251 + 78 Protein_4283 porin family protein -
PRW96_RS21895 (PRW96_21895) 4434351..4435103 + 753 WP_001785756.1 non-specific acid phosphatase -
PRW96_RS21900 (PRW96_21900) 4435344..4435835 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PRW96_RS21905 (PRW96_21905) 4435832..4436125 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PRW96_RS21910 (PRW96_21910) 4436442..4436664 + 223 Protein_4287 hypothetical protein -
PRW96_RS21915 (PRW96_21915) 4436930..4437805 + 876 WP_000921674.1 AraC family transcriptional regulator -
PRW96_RS21920 (PRW96_21920) 4437802..4438089 + 288 WP_001269916.1 transcriptional regulator RtsB -
PRW96_RS21925 (PRW96_21925) 4438112..4438328 + 217 Protein_4290 hypothetical protein -
PRW96_RS21930 (PRW96_21930) 4438336..4438680 + 345 WP_100680417.1 Ig-like domain-containing protein -
PRW96_RS21935 (PRW96_21935) 4438967..4439872 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T270284 WP_000626103.1 NZ_CP117292:c4435835-4435344 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT270284 WP_001110456.1 NZ_CP117292:c4436125-4435832 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References