Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4312942..4313720 | Replicon | chromosome |
| Accession | NZ_CP117292 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain S4 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1C2 |
| Locus tag | PRW96_RS21195 | Protein ID | WP_000622308.1 |
| Coordinates | 4312942..4313430 (-) | Length | 163 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1C3 |
| Locus tag | PRW96_RS21200 | Protein ID | WP_001143724.1 |
| Coordinates | 4313427..4313720 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PRW96_RS21180 (PRW96_21180) | 4309388..4311673 | + | 2286 | WP_010989300.1 | hypothetical protein | - |
| PRW96_RS21185 (PRW96_21185) | 4311977..4312228 | + | 252 | WP_024131240.1 | hypothetical protein | - |
| PRW96_RS21190 (PRW96_21190) | 4312310..4312762 | + | 453 | WP_000434168.1 | hypothetical protein | - |
| PRW96_RS21195 (PRW96_21195) | 4312942..4313430 | - | 489 | WP_000622308.1 | GNAT family N-acetyltransferase | Toxin |
| PRW96_RS21200 (PRW96_21200) | 4313427..4313720 | - | 294 | WP_001143724.1 | DUF1778 domain-containing protein | Antitoxin |
| PRW96_RS21205 (PRW96_21205) | 4314147..4315160 | - | 1014 | WP_000449622.1 | site-specific integrase | - |
| PRW96_RS21210 (PRW96_21210) | 4315324..4316913 | - | 1590 | WP_000488995.1 | TraI domain-containing protein | - |
| PRW96_RS21215 (PRW96_21215) | 4316897..4318408 | - | 1512 | WP_001120833.1 | UvrD-helicase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 | 4300725..4433641 | 132916 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 163 a.a. Molecular weight: 17538.36 Da Isoelectric Point: 7.3252
>T270283 WP_000622308.1 NZ_CP117292:c4313430-4312942 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA
Download Length: 489 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10906.59 Da Isoelectric Point: 6.3493
>AT270283 WP_001143724.1 NZ_CP117292:c4313720-4313427 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716G941 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716D9M3 |