Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4196054..4196570 Replicon chromosome
Accession NZ_CP117292
Organism Salmonella enterica subsp. enterica serovar Typhi strain S4

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PRW96_RS20580 Protein ID WP_000220578.1
Coordinates 4196054..4196338 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PRW96_RS20585 Protein ID WP_000212724.1
Coordinates 4196328..4196570 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW96_RS20565 (PRW96_20565) 4191266..4192918 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
PRW96_RS20570 (PRW96_20570) 4193327..4195465 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
PRW96_RS20575 (PRW96_20575) 4195586..4196050 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PRW96_RS20580 (PRW96_20580) 4196054..4196338 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRW96_RS20585 (PRW96_20585) 4196328..4196570 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PRW96_RS20590 (PRW96_20590) 4196648..4198561 - 1914 WP_001212152.1 BglG family transcription antiterminator -
PRW96_RS20595 (PRW96_20595) 4198578..4199318 - 741 WP_000779260.1 KDGP aldolase family protein -
PRW96_RS20600 (PRW96_20600) 4199315..4200433 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PRW96_RS20605 (PRW96_20605) 4200417..4201550 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T270282 WP_000220578.1 NZ_CP117292:c4196338-4196054 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270282 WP_000212724.1 NZ_CP117292:c4196570-4196328 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References