Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3513411..3514031 Replicon chromosome
Accession NZ_CP117292
Organism Salmonella enterica subsp. enterica serovar Typhi strain S4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PRW96_RS17400 Protein ID WP_001280991.1
Coordinates 3513813..3514031 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PRW96_RS17395 Protein ID WP_000344807.1
Coordinates 3513411..3513785 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW96_RS17385 (PRW96_17385) 3508550..3509743 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PRW96_RS17390 (PRW96_17390) 3509766..3512915 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PRW96_RS17395 (PRW96_17395) 3513411..3513785 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PRW96_RS17400 (PRW96_17400) 3513813..3514031 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PRW96_RS17405 (PRW96_17405) 3514210..3514761 + 552 WP_001278793.1 maltose O-acetyltransferase -
PRW96_RS17410 (PRW96_17410) 3514879..3515349 + 471 WP_000136183.1 YlaC family protein -
PRW96_RS17415 (PRW96_17415) 3515405..3515545 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PRW96_RS17420 (PRW96_17420) 3515551..3515811 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PRW96_RS17425 (PRW96_17425) 3516036..3517586 + 1551 WP_000213129.1 EAL domain-containing protein -
PRW96_RS17435 (PRW96_17435) 3517817..3518206 + 390 WP_000961285.1 MGMT family protein -
PRW96_RS17440 (PRW96_17440) 3518239..3518808 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270280 WP_001280991.1 NZ_CP117292:3513813-3514031 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T270280 NZ_CP117292:3513813-3514031 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270280 WP_000344807.1 NZ_CP117292:3513411-3513785 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT270280 NZ_CP117292:3513411-3513785 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References