Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 809171..809695 Replicon chromosome
Accession NC_017568
Organism Staphylococcus pseudintermedius ED99

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag SPSE_RS03530 Protein ID WP_014613379.1
Coordinates 809342..809695 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag SPSE_RS03525 Protein ID WP_014613378.1
Coordinates 809171..809341 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPSE_RS03500 805060..805533 + 474 WP_014613373.1 PH domain-containing protein -
SPSE_RS03505 805526..807055 + 1530 WP_014613374.1 PH domain-containing protein -
SPSE_RS03510 807039..807557 + 519 WP_014613375.1 PH domain-containing protein -
SPSE_RS03515 807554..807904 + 351 WP_014613376.1 holo-ACP synthase -
SPSE_RS03520 807938..809086 + 1149 WP_014613377.1 alanine racemase -
SPSE_RS03525 809171..809341 + 171 WP_014613378.1 hypothetical protein Antitoxin
SPSE_RS03530 809342..809695 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SPSE_RS03535 809753..810757 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
SPSE_RS03540 810836..811162 + 327 WP_014613381.1 anti-sigma factor antagonist -
SPSE_RS03545 811162..811641 + 480 WP_031253870.1 anti-sigma B factor RsbW -
SPSE_RS03550 811616..812386 + 771 WP_014613383.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T27028 WP_014613379.1 NC_017568:809342-809695 [Staphylococcus pseudintermedius ED99]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T27028 NC_017568:809342-809695 [Staphylococcus pseudintermedius ED99]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT27028 WP_014613378.1 NC_017568:809171-809341 [Staphylococcus pseudintermedius ED99]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT27028 NC_017568:809171-809341 [Staphylococcus pseudintermedius ED99]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References