Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1013419..1014044 Replicon chromosome
Accession NZ_CP117292
Organism Salmonella enterica subsp. enterica serovar Typhi strain S4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PRW96_RS04905 Protein ID WP_000911334.1
Coordinates 1013646..1014044 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PRW96_RS04900 Protein ID WP_000557549.1
Coordinates 1013419..1013646 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW96_RS04870 (PRW96_04870) 1008590..1009309 + 720 WP_000082599.1 Rha family transcriptional regulator -
PRW96_RS04875 (PRW96_04875) 1009313..1009516 + 204 WP_000184036.1 hypothetical protein -
PRW96_RS04880 (PRW96_04880) 1009599..1010054 + 456 WP_223229661.1 hypothetical protein -
PRW96_RS04885 (PRW96_04885) 1010156..1011277 + 1122 WP_000028980.1 hypothetical protein -
PRW96_RS04890 (PRW96_04890) 1011910..1012716 - 807 WP_077905073.1 DUF1460 domain-containing protein -
PRW96_RS04895 (PRW96_04895) 1012991..1013242 - 252 WP_001540858.1 hypothetical protein -
PRW96_RS04900 (PRW96_04900) 1013419..1013646 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PRW96_RS04905 (PRW96_04905) 1013646..1014044 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PRW96_RS04910 (PRW96_04910) 1014851..1015387 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PRW96_RS04915 (PRW96_04915) 1015434..1016066 + 633 WP_000835268.1 YfdX family protein -
PRW96_RS04920 (PRW96_04920) 1016785..1017366 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1006338..1022489 16151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T270274 WP_000911334.1 NZ_CP117292:1013646-1014044 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270274 WP_000557549.1 NZ_CP117292:1013419-1013646 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References