Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 996654..997302 Replicon chromosome
Accession NZ_CP117292
Organism Salmonella enterica subsp. enterica serovar Typhi strain S4

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag PRW96_RS04815 Protein ID WP_000244762.1
Coordinates 996901..997302 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PRW96_RS04810 Protein ID WP_000351186.1
Coordinates 996654..996920 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW96_RS04790 (PRW96_04790) 992582..994015 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
PRW96_RS04795 (PRW96_04795) 994174..994485 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
PRW96_RS04800 (PRW96_04800) 994649..995308 + 660 WP_000250289.1 hemolysin III family protein -
PRW96_RS04805 (PRW96_04805) 995424..996404 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
PRW96_RS04810 (PRW96_04810) 996654..996920 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PRW96_RS04815 (PRW96_04815) 996901..997302 + 402 WP_000244762.1 protein YgfX Toxin
PRW96_RS04820 (PRW96_04820) 997367..997888 - 522 WP_001055885.1 flavodoxin FldB -
PRW96_RS04825 (PRW96_04825) 998001..998897 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PRW96_RS04830 (PRW96_04830) 998921..999634 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PRW96_RS04835 (PRW96_04835) 999640..1001373 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T270273 WP_000244762.1 NZ_CP117292:996901-997302 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270273 WP_000351186.1 NZ_CP117292:996654-996920 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References