Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 204810..205570 | Replicon | chromosome |
| Accession | NZ_CP117292 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain S4 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q8Z2B1 |
| Locus tag | PRW96_RS00960 | Protein ID | WP_000533908.1 |
| Coordinates | 205085..205570 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | Q8Z2B2 |
| Locus tag | PRW96_RS00955 | Protein ID | WP_000965889.1 |
| Coordinates | 204810..205097 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PRW96_RS00935 (PRW96_00935) | 200215..201126 | + | 912 | WP_001168555.1 | glycine--tRNA ligase subunit alpha | - |
| PRW96_RS00940 (PRW96_00940) | 201136..203205 | + | 2070 | WP_001291805.1 | glycine--tRNA ligase subunit beta | - |
| PRW96_RS00945 (PRW96_00945) | 203595..204023 | + | 429 | Protein_187 | IS3 family transposase | - |
| PRW96_RS00950 (PRW96_00950) | 204165..204632 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| PRW96_RS00955 (PRW96_00955) | 204810..205097 | + | 288 | WP_000965889.1 | DUF1778 domain-containing protein | Antitoxin |
| PRW96_RS00960 (PRW96_00960) | 205085..205570 | + | 486 | WP_000533908.1 | GNAT family N-acetyltransferase | Toxin |
| PRW96_RS00965 (PRW96_00965) | 205941..206480 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| PRW96_RS00970 (PRW96_00970) | 206655..206867 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| PRW96_RS00975 (PRW96_00975) | 207158..207445 | - | 288 | Protein_193 | HTH-type transcriptional regulator | - |
| PRW96_RS00980 (PRW96_00980) | 207884..208594 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| PRW96_RS00985 (PRW96_00985) | 208644..209618 | - | 975 | WP_000804690.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| PRW96_RS00990 (PRW96_00990) | 209837..210499 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17689.38 Da Isoelectric Point: 9.8719
>T270270 WP_000533908.1 NZ_CP117292:205085-205570 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10964.59 Da Isoelectric Point: 4.6811
>AT270270 WP_000965889.1 NZ_CP117292:204810-205097 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A714MHS9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A752RW74 |