Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1390555..1391175 Replicon chromosome
Accession NZ_CP117291
Organism Salmonella enterica subsp. enterica serovar Typhi strain S5

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PRW97_RS06745 Protein ID WP_001280991.1
Coordinates 1390555..1390773 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PRW97_RS06750 Protein ID WP_000344807.1
Coordinates 1390801..1391175 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW97_RS06705 (PRW97_06705) 1385778..1386347 + 570 WP_000779802.1 YbaY family lipoprotein -
PRW97_RS06710 (PRW97_06710) 1386380..1386769 - 390 WP_000961285.1 MGMT family protein -
PRW97_RS06720 (PRW97_06720) 1387000..1388550 - 1551 WP_000213129.1 EAL domain-containing protein -
PRW97_RS06725 (PRW97_06725) 1388775..1389035 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PRW97_RS06730 (PRW97_06730) 1389041..1389181 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PRW97_RS06735 (PRW97_06735) 1389237..1389707 - 471 WP_000136183.1 YlaC family protein -
PRW97_RS06740 (PRW97_06740) 1389825..1390376 - 552 WP_001278793.1 maltose O-acetyltransferase -
PRW97_RS06745 (PRW97_06745) 1390555..1390773 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PRW97_RS06750 (PRW97_06750) 1390801..1391175 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PRW97_RS06755 (PRW97_06755) 1391671..1394820 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PRW97_RS06760 (PRW97_06760) 1394843..1396036 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270259 WP_001280991.1 NZ_CP117291:c1390773-1390555 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270259 WP_000344807.1 NZ_CP117291:c1391175-1390801 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References