Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4633744..4634360 Replicon chromosome
Accession NZ_CP117290
Organism Salmonella enterica subsp. enterica serovar Typhi strain S6

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag PRW98_RS22820 Protein ID WP_000238494.1
Coordinates 4633744..4634118 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag PRW98_RS22825 Protein ID WP_001523745.1
Coordinates 4634118..4634360 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW98_RS22805 (PRW98_22805) 4631246..4632148 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
PRW98_RS22810 (PRW98_22810) 4632145..4632780 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PRW98_RS22815 (PRW98_22815) 4632777..4633706 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
PRW98_RS22820 (PRW98_22820) 4633744..4634118 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
PRW98_RS22825 (PRW98_22825) 4634118..4634360 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
PRW98_RS22830 (PRW98_22830) 4634565..4635494 + 930 WP_001162859.1 alpha/beta hydrolase -
PRW98_RS22835 (PRW98_22835) 4635580..4635891 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
PRW98_RS22840 (PRW98_22840) 4635888..4636334 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PRW98_RS22845 (PRW98_22845) 4636349..4637290 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PRW98_RS22850 (PRW98_22850) 4637335..4637772 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
PRW98_RS22855 (PRW98_22855) 4637769..4638641 - 873 WP_000921423.1 virulence factor BrkB family protein -
PRW98_RS22860 (PRW98_22860) 4638635..4639234 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T270253 WP_000238494.1 NZ_CP117290:c4634118-4633744 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT270253 WP_001523745.1 NZ_CP117290:c4634360-4634118 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References