Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3903568..3904144 Replicon chromosome
Accession NZ_CP117290
Organism Salmonella enterica subsp. enterica serovar Typhi strain S6

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PRW98_RS19215 Protein ID WP_001131963.1
Coordinates 3903857..3904144 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PRW98_RS19210 Protein ID WP_000063142.1
Coordinates 3903568..3903870 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRW98_RS19195 (PRW98_19195) 3900078..3902228 + 2151 WP_000379934.1 pyruvate/proton symporter BtsT -
PRW98_RS19200 (PRW98_19200) 3902323..3902526 + 204 WP_000460616.1 YbdD/YjiX family protein -
PRW98_RS19205 (PRW98_19205) 3902537..3903493 + 957 WP_000187846.1 GTPase -
PRW98_RS19210 (PRW98_19210) 3903568..3903870 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PRW98_RS19215 (PRW98_19215) 3903857..3904144 - 288 WP_001131963.1 BrnT family toxin Toxin
PRW98_RS19220 (PRW98_19220) 3904397..3905311 - 915 WP_000290518.1 restriction endonuclease -
PRW98_RS19225 (PRW98_19225) 3905509..3909018 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270249 WP_001131963.1 NZ_CP117290:c3904144-3903857 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT270249 WP_000063142.1 NZ_CP117290:c3903870-3903568 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References