Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2134568..2135811 Replicon chromosome
Accession NZ_CP117289
Organism Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag MGCS35823_RS10590 Protein ID WP_084916287.1
Coordinates 2134568..2135335 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MGCS35823_RS10595 Protein ID WP_084916288.1
Coordinates 2135335..2135811 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGCS35823_RS10565 (MGCS35823_04316) 2129847..2130947 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
MGCS35823_RS10570 (MGCS35823_04318) 2130944..2131549 + 606 WP_084916284.1 hypothetical protein -
MGCS35823_RS10575 (MGCS35823_04320) 2131747..2132352 + 606 WP_001040933.1 replication protein -
MGCS35823_RS10580 (MGCS35823_04322) 2132345..2132593 + 249 WP_003055530.1 MerR family transcriptional regulator -
MGCS35823_RS10585 (MGCS35823_04324) 2132682..2133947 + 1266 WP_084916286.1 site-specific integrase -
MGCS35823_RS10590 (MGCS35823_04326) 2134568..2135335 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
MGCS35823_RS10595 (MGCS35823_04328) 2135335..2135811 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
MGCS35823_RS10600 (MGCS35823_04330) 2135966..2136133 - 168 Protein_2033 peptidylprolyl isomerase -
MGCS35823_RS10605 (MGCS35823_04332) 2136396..2137559 - 1164 WP_084916290.1 MFS transporter -
MGCS35823_RS10610 2137546..2137845 - 300 WP_275910569.1 arginase family protein -
MGCS35823_RS10615 2137872..2138324 - 453 WP_275910570.1 arginase family protein -
MGCS35823_RS10620 2138321..2138809 - 489 WP_275910571.1 SPASM domain-containing protein -
MGCS35823_RS10625 2138838..2139500 - 663 WP_275910572.1 radical SAM protein -
MGCS35823_RS10630 (MGCS35823_04338) 2139591..2140454 - 864 Protein_2039 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2132682..2153330 20648
- flank IS/Tn - - 2139840..2140454 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T270239 WP_084916287.1 NZ_CP117289:c2135335-2134568 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT270239 WP_084916288.1 NZ_CP117289:c2135811-2135335 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References