Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2178514..2179757 Replicon chromosome
Accession NZ_CP117288
Organism Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag MGCS35957_RS10845 Protein ID WP_084916287.1
Coordinates 2178514..2179281 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MGCS35957_RS10850 Protein ID WP_084916288.1
Coordinates 2179281..2179757 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGCS35957_RS10820 (MGCS35957_04430) 2173793..2174893 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
MGCS35957_RS10825 (MGCS35957_04432) 2174890..2175495 + 606 WP_084916284.1 hypothetical protein -
MGCS35957_RS10830 (MGCS35957_04434) 2175693..2176298 + 606 WP_001040933.1 replication protein -
MGCS35957_RS10835 (MGCS35957_04436) 2176291..2176539 + 249 WP_003055530.1 MerR family transcriptional regulator -
MGCS35957_RS10840 (MGCS35957_04438) 2176628..2177893 + 1266 WP_084916286.1 site-specific integrase -
MGCS35957_RS10845 (MGCS35957_04440) 2178514..2179281 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
MGCS35957_RS10850 (MGCS35957_04442) 2179281..2179757 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
MGCS35957_RS10855 (MGCS35957_04444) 2179912..2180079 - 168 Protein_2098 peptidylprolyl isomerase -
MGCS35957_RS10860 (MGCS35957_04446) 2180342..2181508 - 1167 WP_227986119.1 MFS transporter -
MGCS35957_RS10865 (MGCS35957_04448) 2181492..2182268 - 777 WP_061600517.1 arginase family protein -
MGCS35957_RS10870 (MGCS35957_04450) 2182265..2183443 - 1179 WP_159333946.1 radical SAM protein -
MGCS35957_RS10875 (MGCS35957_04452) 2183534..2184397 - 864 Protein_2102 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2156308..2192274 35966
- flank IS/Tn - - 2183783..2184397 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T270236 WP_084916287.1 NZ_CP117288:c2179281-2178514 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT270236 WP_084916288.1 NZ_CP117288:c2179757-2179281 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References