270233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2103352..2104595 Replicon chromosome
Accession NZ_CP117287
Organism Streptococcus dysgalactiae subsp. equisimilis strain MGCS36044

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag MGCS36044_RS10325 Protein ID WP_084916287.1
Coordinates 2103352..2104119 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MGCS36044_RS10330 Protein ID WP_084916288.1
Coordinates 2104119..2104595 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGCS36044_RS10300 (MGCS36044_04156) 2098631..2099731 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
MGCS36044_RS10305 (MGCS36044_04158) 2099728..2100333 + 606 WP_084916284.1 hypothetical protein -
MGCS36044_RS10310 (MGCS36044_04160) 2100531..2101136 + 606 WP_001040933.1 replication protein -
MGCS36044_RS10315 (MGCS36044_04162) 2101129..2101377 + 249 WP_003055530.1 MerR family transcriptional regulator -
MGCS36044_RS10320 (MGCS36044_04164) 2101466..2102731 + 1266 WP_084916286.1 site-specific integrase -
MGCS36044_RS10325 (MGCS36044_04166) 2103352..2104119 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
MGCS36044_RS10330 (MGCS36044_04168) 2104119..2104595 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
MGCS36044_RS10335 (MGCS36044_04170) 2104750..2104917 - 168 Protein_1980 peptidylprolyl isomerase -
MGCS36044_RS10340 (MGCS36044_04172) 2105180..2106343 - 1164 WP_084916290.1 MFS transporter -
MGCS36044_RS10345 (MGCS36044_04174) 2106330..2107106 - 777 WP_061600517.1 arginase family protein -
MGCS36044_RS10350 (MGCS36044_04176) 2107103..2108281 - 1179 WP_159333946.1 radical SAM protein -
MGCS36044_RS10355 (MGCS36044_04178) 2108372..2109235 - 864 WP_159333973.1 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2081146..2117112 35966
- flank IS/Tn - - 2108372..2109235 863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T270233 WP_084916287.1 NZ_CP117287:c2104119-2103352 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT270233 WP_084916288.1 NZ_CP117287:c2104595-2104119 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References