270230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2157802..2159045 Replicon chromosome
Accession NZ_CP117285
Organism Streptococcus dysgalactiae subsp. equisimilis strain MGCS36083

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag MGCS36083_RS10670 Protein ID WP_084916287.1
Coordinates 2157802..2158569 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MGCS36083_RS10675 Protein ID WP_084916288.1
Coordinates 2158569..2159045 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGCS36083_RS10645 (MGCS36083_04326) 2153081..2154181 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
MGCS36083_RS10650 (MGCS36083_04328) 2154178..2154783 + 606 WP_084916284.1 hypothetical protein -
MGCS36083_RS10655 (MGCS36083_04330) 2154981..2155586 + 606 WP_001040933.1 replication protein -
MGCS36083_RS10660 (MGCS36083_04332) 2155579..2155827 + 249 WP_003055530.1 MerR family transcriptional regulator -
MGCS36083_RS10665 (MGCS36083_04334) 2155916..2157181 + 1266 WP_084916286.1 site-specific integrase -
MGCS36083_RS10670 (MGCS36083_04336) 2157802..2158569 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
MGCS36083_RS10675 (MGCS36083_04338) 2158569..2159045 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
MGCS36083_RS10680 (MGCS36083_04340) 2159200..2159367 - 168 Protein_2049 peptidylprolyl isomerase -
MGCS36083_RS10685 (MGCS36083_04342) 2159630..2160793 - 1164 WP_084916290.1 MFS transporter -
MGCS36083_RS10690 (MGCS36083_04344) 2160780..2161556 - 777 WP_061600517.1 arginase family protein -
MGCS36083_RS10695 (MGCS36083_04346) 2161553..2162731 - 1179 WP_159333946.1 radical SAM protein -
MGCS36083_RS10700 (MGCS36083_04348) 2162822..2163685 - 864 Protein_2053 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2135596..2171562 35966
- flank IS/Tn - - 2163071..2163685 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T270230 WP_084916287.1 NZ_CP117285:c2158569-2157802 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT270230 WP_084916288.1 NZ_CP117285:c2159045-2158569 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References