Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4188479..4189151 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag Y11_RS19025 Protein ID WP_005166047.1
Coordinates 4188726..4189151 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag Y11_RS19020 Protein ID WP_004390965.1
Coordinates 4188479..4188745 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS18995 4184078..4184680 - 603 WP_005164134.1 HD domain-containing protein -
Y11_RS19000 4184911..4185594 + 684 WP_005180855.1 hemolysin III family protein -
Y11_RS22175 4186006..4187024 - 1019 Protein_3707 IS110 family transposase -
Y11_RS19015 4187220..4188212 - 993 WP_005166051.1 tRNA-modifying protein YgfZ -
Y11_RS19020 4188479..4188745 + 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
Y11_RS19025 4188726..4189151 + 426 WP_005166047.1 protein YgfX Toxin
Y11_RS19030 4189151..4189849 + 699 WP_005166045.1 two-component system response regulator CreB -
Y11_RS19035 4189860..4191282 + 1423 Protein_3712 two-component system sensor histidine kinase CreC -
Y11_RS19040 4191374..4192795 + 1422 WP_005166043.1 cell envelope integrity protein CreD -
Y11_RS19045 4192854..4193372 - 519 WP_005166042.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T27023 WP_005166047.1 NC_017564:4188726-4189151 [Yersinia enterocolitica subsp. palearctica Y11]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T27023 NC_017564:4188726-4189151 [Yersinia enterocolitica subsp. palearctica Y11]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT27023 WP_004390965.1 NC_017564:4188479-4188745 [Yersinia enterocolitica subsp. palearctica Y11]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT27023 NC_017564:4188479-4188745 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References