Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 891553..892985 | Replicon | chromosome |
| Accession | NZ_CP117285 | ||
| Organism | Streptococcus dysgalactiae subsp. equisimilis strain MGCS36083 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | Q8DZ35 |
| Locus tag | MGCS36083_RS04585 | Protein ID | WP_001030302.1 |
| Coordinates | 891553..892398 (-) | Length | 282 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | Q8DZ36 |
| Locus tag | MGCS36083_RS04590 | Protein ID | WP_000037239.1 |
| Coordinates | 892395..892985 (-) | Length | 197 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MGCS36083_RS04580 (MGCS36083_01850) | 888666..891467 | + | 2802 | WP_000656698.1 | phage tail tip lysozyme | - |
| MGCS36083_RS04585 (MGCS36083_01852) | 891553..892398 | - | 846 | WP_001030302.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| MGCS36083_RS04590 (MGCS36083_01854) | 892395..892985 | - | 591 | WP_000037239.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 878299..995059 | 116760 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 282 a.a. Molecular weight: 32414.90 Da Isoelectric Point: 5.2111
>T270229 WP_001030302.1 NZ_CP117285:c892398-891553 [Streptococcus dysgalactiae subsp. equisimilis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD
Download Length: 846 bp
Antitoxin
Download Length: 197 a.a. Molecular weight: 23074.63 Da Isoelectric Point: 7.8056
>AT270229 WP_000037239.1 NZ_CP117285:c892985-892395 [Streptococcus dysgalactiae subsp. equisimilis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
Download Length: 591 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A8D822 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7ZET8 |