Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2096655..2097898 Replicon chromosome
Accession NZ_CP117284
Organism Streptococcus dysgalactiae subsp. equisimilis strain MGCS36089

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag MGCS36089_RS10265 Protein ID WP_084916287.1
Coordinates 2096655..2097422 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MGCS36089_RS10270 Protein ID WP_084916288.1
Coordinates 2097422..2097898 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGCS36089_RS10240 (MGCS36089_04170) 2091934..2093034 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
MGCS36089_RS10245 (MGCS36089_04172) 2093031..2093636 + 606 WP_084916284.1 hypothetical protein -
MGCS36089_RS10250 (MGCS36089_04174) 2093834..2094439 + 606 WP_001040933.1 replication protein -
MGCS36089_RS10255 (MGCS36089_04176) 2094432..2094680 + 249 WP_003055530.1 MerR family transcriptional regulator -
MGCS36089_RS10260 (MGCS36089_04178) 2094769..2096034 + 1266 WP_084916286.1 site-specific integrase -
MGCS36089_RS10265 (MGCS36089_04180) 2096655..2097422 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
MGCS36089_RS10270 (MGCS36089_04182) 2097422..2097898 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
MGCS36089_RS10275 (MGCS36089_04184) 2098053..2098220 - 168 Protein_1972 peptidylprolyl isomerase -
MGCS36089_RS10280 (MGCS36089_04186) 2098483..2099649 - 1167 WP_227986119.1 MFS transporter -
MGCS36089_RS10285 (MGCS36089_04188) 2099633..2100409 - 777 WP_061600517.1 arginase family protein -
MGCS36089_RS10290 (MGCS36089_04190) 2100406..2101584 - 1179 WP_159333946.1 radical SAM protein -
MGCS36089_RS10295 (MGCS36089_04192) 2101675..2102538 - 864 Protein_1976 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2074449..2110415 35966
- flank IS/Tn - - 2101924..2102538 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T270227 WP_084916287.1 NZ_CP117284:c2097422-2096655 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT270227 WP_084916288.1 NZ_CP117284:c2097898-2097422 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References