Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 883997..885429 | Replicon | chromosome |
| Accession | NZ_CP117284 | ||
| Organism | Streptococcus dysgalactiae subsp. equisimilis strain MGCS36089 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | Q8DZ35 |
| Locus tag | MGCS36089_RS04525 | Protein ID | WP_001030302.1 |
| Coordinates | 883997..884842 (-) | Length | 282 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | Q8DZ36 |
| Locus tag | MGCS36089_RS04530 | Protein ID | WP_000037239.1 |
| Coordinates | 884839..885429 (-) | Length | 197 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MGCS36089_RS04520 (MGCS36089_01824) | 881110..883911 | + | 2802 | WP_000656698.1 | phage tail tip lysozyme | - |
| MGCS36089_RS04525 (MGCS36089_01826) | 883997..884842 | - | 846 | WP_001030302.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| MGCS36089_RS04530 (MGCS36089_01828) | 884839..885429 | - | 591 | WP_000037239.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | scpA / lmb | 868727..1120861 | 252134 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 282 a.a. Molecular weight: 32414.90 Da Isoelectric Point: 5.2111
>T270226 WP_001030302.1 NZ_CP117284:c884842-883997 [Streptococcus dysgalactiae subsp. equisimilis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD
Download Length: 846 bp
Antitoxin
Download Length: 197 a.a. Molecular weight: 23074.63 Da Isoelectric Point: 7.8056
>AT270226 WP_000037239.1 NZ_CP117284:c885429-884839 [Streptococcus dysgalactiae subsp. equisimilis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
Download Length: 591 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A8D822 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7ZET8 |