Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1170256..1171745 Replicon plasmid unnamed1
Accession NZ_CP117268
Organism Rhizobium rhododendri strain rho-6.2

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PR018_RS23135 Protein ID WP_142832066.1
Coordinates 1170256..1171518 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PR018_RS23140 Protein ID WP_111217051.1
Coordinates 1171515..1171745 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PR018_RS23115 (PR018_23120) 1166118..1166546 - 429 WP_142832060.1 MucR family transcriptional regulator -
PR018_RS23120 (PR018_23125) 1167162..1167932 + 771 WP_142832062.1 SDR family NAD(P)-dependent oxidoreductase -
PR018_RS23125 (PR018_23130) 1168163..1168972 + 810 WP_142832064.1 mechanosensitive ion channel -
PR018_RS23130 (PR018_23135) 1169367..1169646 - 280 Protein_1050 helix-turn-helix transcriptional regulator -
PR018_RS23135 (PR018_23140) 1170256..1171518 - 1263 WP_142832066.1 type II toxin-antitoxin system HipA family toxin Toxin
PR018_RS23140 (PR018_23145) 1171515..1171745 - 231 WP_111217051.1 helix-turn-helix transcriptional regulator Antitoxin
PR018_RS23145 (PR018_23150) 1172336..1173967 + 1632 WP_142832100.1 FAD-dependent oxidoreductase -
PR018_RS23150 (PR018_23155) 1174171..1174401 + 231 WP_142832068.1 DUF6429 family protein -
PR018_RS23155 (PR018_23160) 1175346..1175525 + 180 WP_142832070.1 DUF2274 domain-containing protein -
PR018_RS23160 (PR018_23165) 1175643..1176023 + 381 WP_142832071.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..1530638 1530638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45280.02 Da        Isoelectric Point: 6.1805

>T270223 WP_142832066.1 NZ_CP117268:c1171518-1170256 [Rhizobium rhododendri]
MTVRVLNVWWNGRIVGQFTQDQHGDIGFAYAEAWLEDEKALPLSVSLPKRPERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPIGGGLIADRQTAALDEVGIVRILDALPTRPLLAGQEGLRLSLAGAQSKA
PVVLIDGQVALPLPGQATTHILKPPIARFPGTTENEAFAMRLAAAIGLDVAPVDPRSANGRPFLLVKRYDRHHDGDGVVL
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPGTDIAKLLDAAIFNLVIGNADAHGKNFSILYDHSGPRMA
PLYDLLSTVAYPDLSPKLAMRIGKRATLADMGADGWQAFSKETGVSLPLVRRRVKELTDATGDAIPRLLEDMSPLAADPV
SLNRVAALIADRAKLVSLSI

Download         Length: 1263 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8055.40 Da        Isoelectric Point: 10.5998

>AT270223 WP_111217051.1 NZ_CP117268:c1171745-1171515 [Rhizobium rhododendri]
MAKQVSSPAEIGALVRSTRKAQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILAPGERRK

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References