Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 706831..708320 Replicon plasmid pRt932
Accession NZ_CP117262
Organism Rhizobium tumorigenes strain 932

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PR016_RS21885 Protein ID WP_278332847.1
Coordinates 706831..708093 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PR016_RS21890 Protein ID WP_111217051.1
Coordinates 708090..708320 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PR016_RS21855 (PR016_21855) 702247..702477 + 231 WP_278333116.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
PR016_RS21860 (PR016_21860) 702770..703198 - 429 WP_278332842.1 MucR family transcriptional regulator -
PR016_RS21865 (PR016_21865) 703802..704572 + 771 WP_278332843.1 SDR family NAD(P)-dependent oxidoreductase -
PR016_RS21870 (PR016_21870) 704803..705612 + 810 WP_278332844.1 mechanosensitive ion channel -
PR016_RS21875 (PR016_21875) 705938..706216 - 279 WP_278332845.1 helix-turn-helix transcriptional regulator -
PR016_RS21880 (PR016_21880) 706233..706406 - 174 WP_278332846.1 hypothetical protein -
PR016_RS21885 (PR016_21885) 706831..708093 - 1263 WP_278332847.1 type II toxin-antitoxin system HipA family toxin Toxin
PR016_RS21890 (PR016_21890) 708090..708320 - 231 WP_111217051.1 helix-turn-helix transcriptional regulator Antitoxin
PR016_RS21895 (PR016_21895) 708908..710539 + 1632 WP_278333117.1 FAD-dependent oxidoreductase -
PR016_RS21900 (PR016_21900) 710746..710976 + 231 WP_278333118.1 DUF6429 family protein -
PR016_RS21905 (PR016_21905) 711613..712101 + 489 WP_278332848.1 nuclear transport factor 2 family protein -
PR016_RS21910 (PR016_21910) 712285..713295 + 1011 WP_278332849.1 cellulase family glycosylhydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..756443 756443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45281.01 Da        Isoelectric Point: 5.8976

>T270213 WP_278332847.1 NZ_CP117262:c708093-706831 [Rhizobium tumorigenes]
MTVRVLNVWWNGRIVGQFTQDQHGDIGFAYAEAWLDDEKALPLSVSLPKRPERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPIVGGLIADRQTAALDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKA
PVVLIDGQVALPLPGQATTHILKPPIARFPGTTENEAFAMRLAAAIGLDVAPVDPRSANGRPFLLVNRHDRHHDGDGVVL
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPGTDIAKLLDAAIFNLVIGNADAHGKNFSILYDHSGPRMA
PLYDLLSTVAYPDLSPKLAMRIGKRATLADMDADGWQAFSKETGVSLPLVRRRVKELTDATGDAIPRLLEDMSPLAADPV
SLIRVAALIADRAKLVALSI

Download         Length: 1263 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8055.40 Da        Isoelectric Point: 10.5998

>AT270213 WP_111217051.1 NZ_CP117262:c708320-708090 [Rhizobium tumorigenes]
MAKQVSSPAEIGALVRSTRKAQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILAPGERRK

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References