Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 754335..755824 Replicon plasmid pRt1078
Accession NZ_CP117256
Organism Rhizobium tumorigenes strain 1078

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PR017_RS21240 Protein ID WP_111217053.1
Coordinates 754335..755597 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PR017_RS21245 Protein ID WP_111217051.1
Coordinates 755594..755824 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PR017_RS21220 (PR017_21220) 750199..750627 - 429 WP_111217061.1 MucR family transcriptional regulator -
PR017_RS21225 (PR017_21225) 751236..752006 + 771 WP_111217059.1 SDR family NAD(P)-dependent oxidoreductase -
PR017_RS21230 (PR017_21230) 752237..753046 + 810 WP_111217057.1 mechanosensitive ion channel -
PR017_RS21235 (PR017_21235) 753443..753721 - 279 WP_111217055.1 helix-turn-helix transcriptional regulator -
PR017_RS21240 (PR017_21240) 754335..755597 - 1263 WP_111217053.1 type II toxin-antitoxin system HipA family toxin Toxin
PR017_RS21245 (PR017_21245) 755594..755824 - 231 WP_111217051.1 helix-turn-helix transcriptional regulator Antitoxin
PR017_RS21250 (PR017_21250) 756415..758046 + 1632 WP_111217146.1 FAD-dependent oxidoreductase -
PR017_RS21255 (PR017_21255) 758248..758478 + 231 WP_111217144.1 DUF6429 family protein -
PR017_RS21260 (PR017_21260) 758448..758720 - 273 Protein_700 transposase domain-containing protein -
PR017_RS21265 (PR017_21265) 759124..759612 + 489 WP_111217047.1 nuclear transport factor 2 family protein -
PR017_RS21270 (PR017_21270) 759844..760806 + 963 Protein_702 cellulase family glycosylhydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..834411 834411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-381)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45285.91 Da        Isoelectric Point: 5.4819

>T270201 WP_111217053.1 NZ_CP117256:c755597-754335 [Rhizobium tumorigenes]
MTVRVLNVWWNGRIVGQFTQDQHGDIGFAYAEAWLEDEKALPLSVSLPKRPERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPIGGGLIADRQSAALDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKA
PVVLIDGQVALPLPGQATTHILKPPIARFPGTTENEAFAMRLAAAIGLDVAPVDPRSANGRPFLLVNRYDRHHDGDGVVL
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRWVSARPGTDIAKLLDAAIFNLVIGNADAHGKNFSILYDHSGPRMA
PLYDLLSTVAYPDCSPKLAMRIGKRATLADMDADGWQAFSKETGVSLPLVRRRVKELTDATGDAIPRLLEDMSPLAADPV
SLNRVAALIADRAKLVALSI

Download         Length: 1263 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8055.40 Da        Isoelectric Point: 10.5998

>AT270201 WP_111217051.1 NZ_CP117256:c755824-755594 [Rhizobium tumorigenes]
MAKQVSSPAEIGALVRSTRKAQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILAPGERRK

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References