Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 148643..149258 Replicon plasmid pRt1078
Accession NZ_CP117256
Organism Rhizobium tumorigenes strain 1078

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PR017_RS18480 Protein ID WP_111215804.1
Coordinates 148643..148906 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PR017_RS18485 Protein ID WP_111215803.1
Coordinates 148944..149258 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PR017_RS18455 (PR017_18455) 144178..145194 + 1017 WP_240538814.1 LacI family DNA-binding transcriptional regulator -
PR017_RS18460 (PR017_18460) 145380..145799 - 420 WP_111215811.1 type II toxin-antitoxin system VapC family toxin -
PR017_RS18465 (PR017_18465) 145796..146050 - 255 WP_111215819.1 plasmid stabilization protein -
PR017_RS18470 (PR017_18470) 146218..146981 + 764 WP_111215810.1 IS5 family transposase -
PR017_RS18475 (PR017_18475) 147118..148344 - 1227 WP_111219125.1 IS701 family transposase -
PR017_RS18480 (PR017_18480) 148643..148906 + 264 WP_111215804.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PR017_RS18485 (PR017_18485) 148944..149258 + 315 WP_111215803.1 putative addiction module antidote protein Antitoxin
PR017_RS18490 (PR017_18490) 149527..150315 - 789 WP_240538813.1 transporter substrate-binding domain-containing protein -
PR017_RS18495 (PR017_18495) 150497..152788 + 2292 WP_240538812.1 EAL domain-containing protein -
PR017_RS18500 (PR017_18500) 153125..154180 - 1056 WP_111215798.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..834411 834411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-87)

Antitoxin

Uncharacterized protein HI1420

(6-90)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9986.46 Da        Isoelectric Point: 10.3633

>T270198 WP_111215804.1 NZ_CP117256:148643-148906 [Rhizobium tumorigenes]
MFTIRRTRNYADWIKTLKDFRAQARIADRIDRLAAGNPGDVKPVGEGVSELRINYGPGYRVNFVREGLVVYVLLCRGDKS
TQEKDIR

Download         Length: 264 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11029.32 Da        Isoelectric Point: 4.5994

>AT270198 WP_111215803.1 NZ_CP117256:148944-149258 [Rhizobium tumorigenes]
MQLETFEYDSAEFLGSEEAIAEYLLAASEDGDANHIARALGVVARARGMSDLSRNTGLTRPALYRAISGDGNPEFGTIAK
VAYALGYRLNLVLKSDSGSTAAVK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References