Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2561959..2562547 Replicon chromosome
Accession NZ_CP117255
Organism Rhizobium tumorigenes strain 1078

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PR017_RS12485 Protein ID WP_111218848.1
Coordinates 2561959..2562264 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PR017_RS12490 Protein ID WP_111218850.1
Coordinates 2562257..2562547 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PR017_RS12465 (PR017_12465) 2557103..2557894 + 792 WP_111218840.1 aldolase -
PR017_RS12470 (PR017_12470) 2558147..2559094 - 948 WP_111218842.1 substrate-binding domain-containing protein -
PR017_RS12475 (PR017_12475) 2559168..2560175 - 1008 WP_111219027.1 ABC transporter permease -
PR017_RS12480 (PR017_12480) 2560187..2561707 - 1521 WP_111218844.1 sugar ABC transporter ATP-binding protein -
PR017_RS12485 (PR017_12485) 2561959..2562264 + 306 WP_111218848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PR017_RS12490 (PR017_12490) 2562257..2562547 + 291 WP_111218850.1 putative addiction module antidote protein Antitoxin
PR017_RS12495 (PR017_12495) 2562592..2563902 - 1311 WP_111218852.1 xylose isomerase -
PR017_RS12500 (PR017_12500) 2564017..2565471 - 1455 WP_111218854.1 xylulokinase -
PR017_RS12505 (PR017_12505) 2565496..2566521 - 1026 WP_111218856.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11388.86 Da        Isoelectric Point: 9.9057

>T270195 WP_111218848.1 NZ_CP117255:2561959-2562264 [Rhizobium tumorigenes]
MLELRQTAAFAKWRQRLTDDRARAIIASRLDRLAYGHSGDAQSVGDGVQELRIHYGPGYRIYFKTRGNTLIILLCGGDKS
TQARDISAAKRLLTEWNDDHG

Download         Length: 306 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10158.63 Da        Isoelectric Point: 4.4143

>AT270195 WP_111218850.1 NZ_CP117255:2562257-2562547 [Rhizobium tumorigenes]
MVEKLTPYDPAEDLVSDEAMAVFMGEAFETGDAGYIAHALGVVARAKGMTQIATETGLSREQLYRSFSEAGNPTLKTTMA
VMKALGITLTAKVAAE

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References