Detailed information of TA system TA027019

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3189677..3190261
• Replicon: chromosome
• Accession: NC_017564
• Organism: Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7U7ISC5
• Locus tag: Y11_RS14605
• Protein ID: WP_005165296.1
• Coordinates: 3189677..3190045 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: Y11_RS21990
• Protein ID: WP_129019424.1
• Coordinates: 3190109..3190261 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y11_RS14585	3184884..3185804	+	921	WP_005165286.1	ROK family protein	-
Y11_RS14590	3185889..3186851	+	963	WP_005165289.1	LacI family transcriptional regulator	-
Y11_RS14595	3186885..3187358	-	474	WP_005165291.1	GNAT family N-acetyltransferase	-
Y11_RS14600	3188594..3189448	-	855	WP_005165294.1	DUF4942 domain-containing protein	-
Y11_RS14605	3189677..3190045	-	369	WP_005165296.1	TA system toxin CbtA family protein	Toxin
Y11_RS21990	3190109..3190261	-	153	WP_129019424.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
Y11_RS14610	3190330..3191532	+	1203	WP_005178352.1	IS256 family transposase	-
Y11_RS14615	3191707..3193170	+	1464	WP_005166182.1	alpha/beta hydrolase	-
Y11_RS14620	3193403..3194809	-	1407	WP_005166180.1	filamentous hemagglutinin N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3190330..3191532	1202

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (1-45)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13609.55 Da
• Isoelectric Point: 6.4731

>T27019 WP_005165296.1 NC_017564:c3190045-3189677 [Yersinia enterocolitica subsp. palearctica Y11]
MQTLPVTSKRAAYACLSPVIVWQSMLTYLLEQHYGLVLSDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLARTDHRGF
SCQEQSPFITSIDILRARRATGLMTRMGYQTITSVIRGGKQA

Nucleotide

• Length: 369 bp

>T27019 NC_017564:c3190045-3189677 [Yersinia enterocolitica subsp. palearctica Y11]
ATGCAGACCTTACCTGTCACCTCGAAACGGGCGGCCTACGCTTGCCTATCACCCGTTATTGTCTGGCAATCCATGCTCAC
GTATCTGCTAGAGCAGCATTACGGCCTGGTGCTTAGCGACACCGAGTTCAGTGATGACGCCGTTATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGCTGAATTTCACGGTGGAGAAGTTTGACTTGGCTCGCACCGATCACCGAGGTTTC
TCCTGCCAGGAACAATCTCCCTTTATCACGTCTATCGATATTCTCCGCGCTCGTCGAGCCACCGGTCTGATGACCCGTAT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGGAAAGCAGGCATGA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5593.44 Da
• Isoelectric Point: 4.5803

>AT27019 WP_129019424.1 NC_017564:c3190261-3190109 [Yersinia enterocolitica subsp. palearctica Y11]
MELMLLSGELNPRYQHCVTLYRNGLICEADSLGSQGYVYLAIYPTPQSIA

Nucleotide

• Length: 153 bp

>AT27019 NC_017564:c3190261-3190109 [Yersinia enterocolitica subsp. palearctica Y11]
CTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGCGTCACGTTGTATCGCAATGGCTTGATCTG
CGAAGCCGATAGCCTGGGATCACAGGGTTATGTGTATCTCGCCATTTATCCTACTCCCCAATCAATTGCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7ISC5