Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4224175..4224691 Replicon chromosome
Accession NZ_CP117244
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PQQ30_RS20620 Protein ID WP_000220578.1
Coordinates 4224175..4224459 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ30_RS20625 Protein ID WP_000212724.1
Coordinates 4224449..4224691 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ30_RS20605 (4219387) 4219387..4221039 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
PQQ30_RS20610 (4221448) 4221448..4223586 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ30_RS20615 (4223707) 4223707..4224171 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ30_RS20620 (4224175) 4224175..4224459 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ30_RS20625 (4224449) 4224449..4224691 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ30_RS20630 (4224769) 4224769..4226682 - 1914 WP_001212137.1 BglG family transcription antiterminator -
PQQ30_RS20635 (4226699) 4226699..4227439 - 741 WP_000779263.1 KDGP aldolase family protein -
PQQ30_RS20640 (4227436) 4227436..4228554 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ30_RS20645 (4228538) 4228538..4229671 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T270182 WP_000220578.1 NZ_CP117244:c4224459-4224175 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270182 WP_000212724.1 NZ_CP117244:c4224691-4224449 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References