Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3128527..3129170 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag Y11_RS14375 Protein ID WP_005161957.1
Coordinates 3128751..3129170 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag Y11_RS14370 Protein ID WP_005161959.1
Coordinates 3128527..3128754 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS14345 3123640..3124803 + 1164 WP_005161974.1 mannitol-1-phosphate 5-dehydrogenase -
Y11_RS14350 3125035..3125589 + 555 WP_005161972.1 MltR family transcriptional regulator -
Y11_RS14355 3125586..3126197 - 612 WP_016266331.1 LysE family translocator -
Y11_RS14360 3126465..3127946 + 1482 WP_005161967.1 PLP-dependent aminotransferase family protein -
Y11_RS14365 3128039..3128395 + 357 WP_005161962.1 YibL family ribosome-associated protein -
Y11_RS14370 3128527..3128754 + 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Y11_RS14375 3128751..3129170 + 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
Y11_RS14380 3129324..3129995 - 672 WP_014609259.1 6-N-hydroxylaminopurine resistance protein -
Y11_RS14385 3130074..3132023 - 1950 WP_005161951.1 methyl-accepting chemotaxis protein -
Y11_RS14390 3132347..3132970 - 624 WP_005161946.1 superoxide dismutase [Mn] -
Y11_RS14395 3133097..3133951 - 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T27018 WP_005161957.1 NC_017564:3128751-3129170 [Yersinia enterocolitica subsp. palearctica Y11]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T27018 NC_017564:3128751-3129170 [Yersinia enterocolitica subsp. palearctica Y11]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT27018 WP_005161959.1 NC_017564:3128527-3128754 [Yersinia enterocolitica subsp. palearctica Y11]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT27018 NC_017564:3128527-3128754 [Yersinia enterocolitica subsp. palearctica Y11]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References