Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3529261..3529881 Replicon chromosome
Accession NZ_CP117244
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ30_RS17465 Protein ID WP_001280991.1
Coordinates 3529663..3529881 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ30_RS17460 Protein ID WP_000344807.1
Coordinates 3529261..3529635 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ30_RS17450 (3524400) 3524400..3525593 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ30_RS17455 (3525616) 3525616..3528765 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ30_RS17460 (3529261) 3529261..3529635 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ30_RS17465 (3529663) 3529663..3529881 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ30_RS17470 (3530060) 3530060..3530611 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ30_RS17475 (3530728) 3530728..3531198 + 471 WP_000136181.1 YlaC family protein -
PQQ30_RS17480 (3531254) 3531254..3531394 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ30_RS17485 (3531400) 3531400..3531660 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ30_RS17490 (3531885) 3531885..3533435 + 1551 WP_000213139.1 EAL domain-containing protein -
PQQ30_RS17500 (3533666) 3533666..3534055 + 390 WP_000961285.1 MGMT family protein -
PQQ30_RS17505 (3534088) 3534088..3534657 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270178 WP_001280991.1 NZ_CP117244:3529663-3529881 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270178 WP_000344807.1 NZ_CP117244:3529261-3529635 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References