Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2786335..2787964 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U7IQ60
Locus tag Y11_RS12950 Protein ID WP_005165219.1
Coordinates 2786636..2787964 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A7U7FJW4
Locus tag Y11_RS12945 Protein ID WP_005165217.1
Coordinates 2786335..2786634 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS12930 2781777..2783426 - 1650 WP_005165210.1 Na+/H+ antiporter -
Y11_RS12935 2783641..2785008 - 1368 WP_005165212.1 NCS2 family permease -
Y11_RS12940 2785369..2786040 - 672 WP_005165214.1 glutathione S-transferase -
Y11_RS12945 2786335..2786634 + 300 WP_005165217.1 helix-turn-helix transcriptional regulator Antitoxin
Y11_RS12950 2786636..2787964 + 1329 WP_005165219.1 type II toxin-antitoxin system HipA family toxin Toxin
Y11_RS12955 2788053..2788601 - 549 WP_005165221.1 single-stranded DNA-binding protein SSB1 -
Y11_RS12960 2789130..2791961 + 2832 WP_005165223.1 excinuclease ABC subunit UvrA -
Y11_RS12965 2792020..2792373 - 354 WP_005165225.1 MmcQ/YjbR family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49925.93 Da        Isoelectric Point: 6.8736

>T27017 WP_005165219.1 NC_017564:2786636-2787964 [Yersinia enterocolitica subsp. palearctica Y11]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPSITTIMEILSGSDNASEDRNVFFKAQIIFWLLAATDGHAKNFS
IAHLPGSRYHLTPLYDVLSTHPIIGSGRNQIAVQKSKLAMAVRGSKNYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLAEKILTGLHKQCEKISAML

Download         Length: 1329 bp

>T27017 NC_017564:2786636-2787964 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAGCACGTTGGCTATTGGGAAAAAAATCGAGGCGAAGA
ATCGCTGGTTTATGCCCAAGAATGGTTAGCAAACGAACAAGGCCGACCGCTATCATTATCATTGCCTTTCACTGCCAATA
ATCAGGTTTATAGAGGCAATATTGTCCGGGACTATTTTGATAATTTATTACCCGATAGCGATGATATCCGGCGACGTCTG
GCAACTAAATACCACGCTGACAGCATTAACCCTTTCGATCTATTGTTTGAATTAGGAAGAGATTGTGTCGGTGCAATACA
ATTGCTAACTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TTCTACGAAACTCATTATCTGACAATGCATTTGTGCGCCCTGAACACGATGAGGATCTCAGATTGTCTATCGCAGGGGCA
CAAGAAAAAACAGCTCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTGGGCAGCACTCCCACCACCCATATCTTCAA
ACTTCCGTTGGGCTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTACCGGTCGCCAGTTGTGAAATTGGCCAGTTTGAAGACCAAAAAGCATTGATTGTTGAACGTTTT
GACCGACGTTTATCGCGTGACAAGAGTTGGATCGTCAGATTACCGCAAGAAGATATGTGCCAGGCCACTGGGACTTCTCC
CTTAAAAAAATATCAAATGGATGGTGGCCCCAGTATTACCACCATAATGGAGATTTTGAGTGGTTCGGATAATGCCAGTG
AAGACAGAAACGTCTTCTTTAAAGCACAGATTATTTTCTGGTTATTGGCCGCAACTGATGGACATGCAAAAAACTTTAGC
ATTGCTCATCTCCCCGGGAGTCGTTATCACCTCACGCCACTTTATGACGTGTTATCAACCCATCCGATTATCGGCTCGGG
TCGTAATCAGATTGCGGTTCAAAAATCCAAGTTAGCGATGGCGGTAAGAGGGAGTAAAAATTACTATTTGATTAACCAGA
TCCAACGCCGTCATTGGCGAAAACAGGCAGAATTTGTTGGACTAGGAGCGATTCAAGCTGACACTATTATCGATGAAATA
ATTGCCGCAACCCCACGGGTTATCACACAAGTACAAGCTCAACTTCCGGCTAATTTTCCTGCTGACTTAGCAGAGAAAAT
CCTTACTGGCCTTCATAAACAATGTGAAAAAATCTCGGCAATGCTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11141.78 Da        Isoelectric Point: 8.5374

>AT27017 WP_005165217.1 NC_017564:2786335-2786634 [Yersinia enterocolitica subsp. palearctica Y11]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPTSASVERLFKVLQLLDVELILSEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Download         Length: 300 bp

>AT27017 NC_017564:2786335-2786634 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCGACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGAATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCACCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATCCTTAGTGAGAAAAAAAACGCCAGCGCGCATCCCAATAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IQ60

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJW4

References