Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2199863..2200377 Replicon chromosome
Accession NZ_CP117242
Organism Staphylococcus aureus strain ATCC 14458

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PQQ25_RS11500 Protein ID WP_000581792.1
Coordinates 2199863..2200072 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PQQ25_RS11505 Protein ID WP_000138932.1
Coordinates 2200084..2200377 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ25_RS11480 (2195371) 2195371..2196729 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PQQ25_RS11485 (2196744) 2196744..2197814 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
PQQ25_RS11490 (2198132) 2198132..2199334 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PQQ25_RS11495 (2199598) 2199598..2199735 - 138 WP_000828354.1 Lmo0850 family protein -
PQQ25_RS11500 (2199863) 2199863..2200072 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PQQ25_RS11505 (2200084) 2200084..2200377 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PQQ25_RS11510 (2200543) 2200543..2202027 + 1485 WP_000571549.1 cardiolipin synthase -
PQQ25_RS11515 (2202055) 2202055..2202702 + 648 WP_001187629.1 HD domain-containing protein -
PQQ25_RS11520 (2203515) 2203515..2204387 - 873 WP_000725802.1 membrane protein insertase YidC -
PQQ25_RS11525 (2204473) 2204473..2205114 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T270162 WP_000581792.1 NZ_CP117242:c2200072-2199863 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT270162 WP_000138932.1 NZ_CP117242:c2200377-2200084 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References