Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2180106..2180635 Replicon chromosome
Accession NZ_CP117242
Organism Staphylococcus aureus strain ATCC 14458

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PQQ25_RS11410 Protein ID WP_000621175.1
Coordinates 2180106..2180468 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PQQ25_RS11415 Protein ID WP_000948331.1
Coordinates 2180465..2180635 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ25_RS11390 (2177083) 2177083..2177853 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
PQQ25_RS11395 (2177828) 2177828..2178307 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PQQ25_RS11400 (2178309) 2178309..2178635 - 327 WP_001052491.1 anti-sigma factor antagonist -
PQQ25_RS11405 (2178755) 2178755..2179756 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PQQ25_RS11410 (2180106) 2180106..2180468 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQQ25_RS11415 (2180465) 2180465..2180635 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PQQ25_RS11420 (2180720) 2180720..2181868 - 1149 WP_001281145.1 alanine racemase -
PQQ25_RS11425 (2181934) 2181934..2182293 - 360 WP_000581200.1 holo-ACP synthase -
PQQ25_RS11430 (2182297) 2182297..2182788 - 492 WP_001205910.1 PH domain-containing protein -
PQQ25_RS11435 (2182775) 2182775..2184358 - 1584 WP_001294626.1 PH domain-containing protein -
PQQ25_RS11440 (2184351) 2184351..2184830 - 480 WP_001287088.1 hypothetical protein -
PQQ25_RS11445 (2185039) 2185039..2185599 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T270161 WP_000621175.1 NZ_CP117242:c2180468-2180106 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT270161 WP_000948331.1 NZ_CP117242:c2180635-2180465 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References