Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2435929..2436452 Replicon chromosome
Accession NZ_CP117238
Organism Staphylococcus aureus strain ATCC 23235

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag PQQ27_RS12225 Protein ID WP_000074049.1
Coordinates 2435929..2436195 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag PQQ27_RS12230 Protein ID WP_000587616.1
Coordinates 2436195..2436452 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ27_RS12205 (PQQ27_12205) 2431236..2432423 - 1188 WP_000026189.1 MFS transporter -
PQQ27_RS12210 (PQQ27_12210) 2432819..2433595 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
PQQ27_RS12215 (PQQ27_12215) 2433588..2434250 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
PQQ27_RS12220 (PQQ27_12220) 2434498..2435574 - 1077 WP_001076673.1 M42 family metallopeptidase -
PQQ27_RS12225 (PQQ27_12225) 2435929..2436195 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
PQQ27_RS12230 (PQQ27_12230) 2436195..2436452 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ27_RS12235 (PQQ27_12235) 2436811..2437266 + 456 WP_000732076.1 DUF1307 domain-containing protein -
PQQ27_RS12240 (PQQ27_12240) 2437434..2439011 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
PQQ27_RS12245 (PQQ27_12245) 2439206..2439955 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T270153 WP_000074049.1 NZ_CP117238:c2436195-2435929 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT270153 WP_000587616.1 NZ_CP117238:c2436452-2436195 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References